Our scientific studies

“Athletes give very reliable feedback. When they tell me “you know Marc, it works”, I totally believe them. Take the example of a professional cyclist preparing for the Tour de France. He travels more than 1,000 kilometres per week or an Olympic swimmer, who trains for six hours a day. I believe that the placebo effect does not exist in these people.”

Dr Marc Saramito

Clinically proven efficacy

The efficacy of Melorun® on physical recovery has been evaluated in several populations of athletes, both casual who exercise moderately and professionals who train intensively.
Melorun® has also undergone numerous field tests since it is supported by a sports doctor specialising in micronutrition, who has accompanied many professional athletes.
The results of these studies have demonstrated multiple benefits on recovery, thanks to an action on both physical and mental fatigue, an improvement in several stress and inflammation biomarkers, and muscle and joint protection.

2 clinical studies

4 mechanistique studies

40 mg/day

1 to 2 months

Evolution of oxidative defenses_EN
Evolution of inflammation_EN
Evolution of magnesium level_EN

Oxidative stres, Inflammation or Magnesium level, the modification of these biological markers contributes to the beneficial effects perceived following Melorun® supplementation; on the improvement of physical fatigue, the positive action on joints and muscles and mental performance.

Randomised, double-blind, placebo-controlled clinical study, 40 mg/day for 8 weeks, 38 casual sportspersons subjected to moderate intensity training1

Beyond the effects experienced by subjects, Melorun® has demonstrated its ability to protect the body against oxidative stress and inflammation induced by exercise.

A protective effect has also been demonstrated on the levels of magnesium, an essential mineral for energy metabolism.

By modulating oxidative stress and inflammation, Melorun® helps maintain an optimal level of magnesium and improves the restoration of physiological processes for more vitality and better recovery.

Bien êtreEN

Decrease in physical fatigue and tension

Randomised, double-blind, placebo-controlled clinical study, 40 mg/day for 8 weeks, 38 casual sportspersons subjected to moderate intensity training1

After 8 weeks, subjects felt a significant improvement in their level of fatigue (muscle pain, physical fatigue, sleep disturbance) and physical well-being.

Marqueurs de récupération physiologiqueEN

Consumer study, 40 mg/day for 10 weeks, professional female volleyball team undergoing intense training

These benefits were been experienced by a group of professional athletes undergoing intense training. From the first month, subjects reported a decrease in physical tension and post-exercise fatigue, with increased improvement after two months.


Whether as part of intense or moderate exercise, Melorun® significantly improves the level of fatigue and tension that can be induced by sport.

Performance mentale EN

Decreased stress and mental fatigue

Consumer study, 40 mg/day for 10 weeks, professional female volleyball team undergoing intense training

Beyond the physical sphere, Melorun® is also associated with an improvement in the mental sphere. From the first month, athletes reported a decrease in their stress level and a better capacity for mental preparation.

“The effect on recovery was
very quick. I felt more at ease in my body and better in my head”

(level of satisfaction after two months).

Muscle tissue cross-section_EN
Creatine kinase_EN

Protection of muscle integrity

Mechanistic studies, as part of an eccentric exercise2,3,4

While intense exercise can cause muscle damage that is synonymous with weakened muscles, stiffness and increased risk of injury, Melorun® protects muscle fibres and prevents the onset of these lesions.
In particular, our studies have highlighted a reduction in fibrosis and creatine kinase, markers of muscle damage and typically associated with eccentric-type exercises.

Melorun® has also demonstrated its ability to boost the transition from rapid myosins, suitable for powerful but short contractions, to slow myosins known to allow more energy-efficient contractions.
Melorun® thus promotes adaptation to effort and resistance to fatigue for better sensations during training.

Joint integrity_EN
Joint inflammation_EN

Protection of joint integrity

Mechanistic studies, as part of an eccentric exercise 3,4

During intense exertion, the strong and repeated pressure exerted on our joints can result in premature wear and discomfort. The use of Melorun® is associated with decreased inflammation and degradation of the joint matrix.

The results of these studies have been published in specialised journals.

1Saby M. & al, International Journal of Environmental Research and Public Health 2020

Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

2Notin C. & al, Equine Veterinary Journal, 2010

Supplementation With a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

3Barbé F. & al, 43 ème Journée de la Recherche Équine, 2017

Maintien de l’intégrité musculaire et articulaire: les bénéfices de la Superoxyde Dismutase végétale

4McNicol J. & al, Veterinary science Research, 2020,

Dietary cucumis melo reduces markers of muscle and articular inflammation following high-intensity exercise in horses